AME - 3D-Printed Clinostat Development for Microgravity Cancer Research

We are building a cost-effective, 3D-printed, two-axis clinostat to simulate microgravity for studying its influence on cancer immunotherapy. In the first project phase, we designed and validated a working prototype using 3D printing, servo motors, and a Raspberry Pi control system, achieving ~10⁻² g simulation. The next step is to refine the design for improved stability, humidity/temperature resistance, and precision—targeting ~10⁻⁴ g performance. The student will help redesign and fabricate components, integrate improved control electronics, and test the system under lab and incubator conditions.

 

Name of research group, project, or lab
Xin Lu lab, Department of Biological Sciences
Website
https://biology.nd.edu/labs/lu-lab/
Why join this research group or lab?

Our lab combines engineering innovation with cutting-edge cancer biology to answer space biology questions with real-world biomedical applications. You will join a collaborative, interdisciplinary environment where engineers like yourself provide a unique contribution to biological projects. Specifically, you will lead the work to directly impact experiments on how microgravity influences cancer immunotherapy.

 

Logistics Information:
Project categories
Aerospace and Mechanical Engineering
Student ranks applicable
Sophomore
Junior
Senior
Student qualifications
  • Background in mechanical engineering, robotics, or mechatronics
  • Experience with CAD design and 3D printing
  • Familiarity with Raspberry Pi or Arduino motor control systems
  • Comfortable working with tools and electronics in a lab setting
  • Self-motivated and able to troubleshoot mechanical/electronic issues
Hours per week
2 credits / 6-12 hours
3 credits / 12+ hours
Summer - Full Time
Compensation
Research for Credit
Number of openings
2
Techniques learned
  • Advanced 3D printing and mechanical design optimization
  • Environmental testing in incubator-like conditions
  • Culture and improve engineered immunotherapy, e.g. CAR-T cells
  • Interdisciplinary collaboration between engineering and biomedical research
Project start
Fall 2025
Contact Information:
Mentor
Xin Lu
xlu@nd.edu
Boler Associate Professor
Name of project director or principal investigator
Xin Lu
Email address of project director or principal investigator
xlu@nd.edu
2 sp. | 6 appl.
Hours per week
2 credits / 6-12 hours (+2)
2 credits / 6-12 hours3 credits / 12+ hoursSummer - Full Time
Project categories
Aerospace and Mechanical Engineering