AME - Human Heart Attack on-chip

I am using stem-cell derived cells to build living pieces of human heart and give them heart attacks. This will help understand the mechanics of heart attacks in human hearts. This will also be used to develop new treatments for heart attack-induced damage.

Undergraduate researchers will be able to choose from a number of activities to support this research. You will be able to grow human heart cells from scratch, determine changes in their behavior, assemble heart tissues in microfluidic devices, and determine effects of heart attack conditions.

This will be organized as a smaller project that is a part of the project as a whole. Your work will likely be part of a publication, which you will have the opportunity to be an author on.

Name of research group, project, or lab
Zorlutuna Lab
Website
https://tissueeng.nd.edu
Why join this research group or lab?

The Zorlutuna lab is tackling heart disease and cancer, the two leading causes of death in the US and worldwide. We develop living, human models of these diseases and use them to inform new treatment approaches. Working with heart cells is particularly rewarding - these cells beat as a heart would.

Representative publication
Frank Ketchum CSHL Tissue Engineering Poster.pdf
Logistics Information:
Project categories
Aerospace and Mechanical Engineering
Biological Sciences
Student ranks applicable
Sophomore
Junior
Student qualifications

This is a biology-based project. Should have an understanding of cell biology basics.

Must have experience with wet lab skills. Cell culture preferred.

Hours per week
1 credit / 3-6 hours
2 credits / 6-12 hours
3 credits / 12+ hours
Compensation
Research for Credit
Number of openings
2
Techniques learned

Opportunities to gain experience with organ-on-chip technology, stem cell culture and differentiation, and various cell biological assays: immunostaining, PCR, western blot, as well as related analysis techniques.

Contact Information:
Mentors
Frank Ketchum
fketchum@nd.edu
Graduate Student
Pinar Zorlutuna
pzorlutu@nd.edu
Professor
Name of project director or principal investigator
Frank Ketchum
Email address of project director or principal investigator
fketchum@nd.edu
2 sp. | 29 appl.
Hours per week
1 credit / 3-6 hours (+2)
1 credit / 3-6 hours2 credits / 6-12 hours3 credits / 12+ hours
Project categories
Biological Sciences (+1)
Aerospace and Mechanical EngineeringBiological Sciences