AME - Nanoparticle Imaging Probes for Contrast-Enhanced CT

X-ray computed tomography (CT) is the most widely used clinical diagnostic imaging modality but is currently limited to anatomic imaging, requiring adjunct modalities for molecular imaging. Therefore, the Roeder lab is working to enable molecular imaging capabilities with CT and spectral photon-counting CT (PCCT) using nanoparticle contrast agents. We are investigating new nanoparticle imaging probes designed for leveraging the capabilities of PCCT, enabling multi-modal imaging, immunotargeting specific cell populations, and monitoring drug delivery. Most recently, we developed nanoparticles to enable non-invasive, longitudinal monitoring of tissue scaffold degradation and drug release by CT. 

Examples Publication/Application
 

Name of research group, project, or lab
Roeder Lab
Logistics Information:
Project categories
Aerospace and Mechanical Engineering
Chemical and Biomolecular Engineering
Student ranks applicable
Sophomore
Junior
Senior
Student qualifications

Engineering (preferred) or science background.

Hours per week
2 credits / 6-12 hours
3 credits / 12+ hours
Compensation
Research for Credit
Number of openings
2
Techniques learned

chemical synthesis, characterization, imaging methods, and application of nanoparticles in biomedicine

Project start
Spring 2025
Contact Information:
Mentor
Ryan Roeder
rroeder@nd.edu
Professor
Name of project director or principal investigator
Ryan K. Roeder
Email address of project director or principal investigator
rroeder@nd.edu
2 sp. | 3 appl.
Hours per week
2 credits / 6-12 hours (+1)
2 credits / 6-12 hours3 credits / 12+ hours
Project categories
Chemical and Biomolecular Engineering (+1)
Aerospace and Mechanical EngineeringChemical and Biomolecular Engineering