Exploring RNA Triple Helices and Protein-Binding Partners using Computational Tools

The Brown laboratory is interested in the structure and function of the MALAT1 RNA triple helix and its protein-binding partners, particularly in the context of cancer and Miller-Dieker Syndrome, which is a rare neurogenetic disease. To that end, the lab uses Python, AlphaFold, PyMOL, AutoDock Vina and other computational tools to analyze publicly available "omics" data, examine 3D structure, screen for small molecule binders and generate figures. We have more than 5 computational projects with multiple sub-parts. Therefore, it is easier to discuss project details in person.