Phage-Mimicking Nanoparticles as Broad Spectrum Antibacterials
The development of antibiotic resistance and the resulting emergence of multidrug-resistant bacteria has become one of the main threats in the public health system, commonly leading to nosocomial infections. Many researchers have turned their focus to developing alternative classes of antibacterial systems based on various nanomaterials. We have developed an antibiotic-free nanoparticle system, inspired by naturally occurring bacteriophages, to fight antibiotic-resistant bacteria. Our phage-mimicking nanoparticles (PhaNPs) display structural mimicry of protein-turret distribution on the head structure of bacteriophages. By mimicking phages, we are able to take advantage of their evolutionary constant shape and their high antibacterial activity while avoiding immune reactions of the human body, potentially caused by phages. We synthesized of hierarchically arranged core-shell nanoparticles, with a silica core conjugated with silver-coated gold nanospheres and capped with antibacterial peptides or antibacterial polymers. We will test the different nanoparticle variants against ESKAPEE class of pathogens.
In this project the students will get exposure to (a) synthesis of novel nanoparticles, (b) sterile cell culture techniques, (c) execute multiple modes nanoparticles formulations for antibacterial testing (ON-Demand, stimuli dependent, topical, intravenous etc.) and (d) execute in vitro cell and in vivo mouse studies that show low dose, high-efficacy antibacterial activity and improved biocompatibility in the sample group. This project is open to any students with a science or engineering background.
oining the PD Nano research group (Nallathamby Lab) as an undergraduate offers a high-impact, multidisciplinary experience at the intersection of nanotechnology and global health.
1. Why this project is important
The project addresses the global crisis of antibiotic resistance. As "superbugs" (ESKAPEE pathogens) become immune to traditional drugs, we need new weapons.
- Bio-Inspired Innovation: Instead of using chemicals bacteria can evolve to resist, this project uses Phage-Mimicking Nanoparticles (PhaNPs).
- The Advantage: It mimics the physical structure of naturally occurring viruses (bacteriophages) to kill bacteria while avoiding the human immune system reactions that real viruses often trigger.
2. Why join as an undergraduate?
- Skill Acquisition: You gain a rare combination of "wet lab" biological skills and "dry lab" material synthesis skills.
- Professional Edge: Having experience with in vivo (animal) studies and novel nanomaterials is a significant differentiator for medical school or PhD applications.
- Direct Mentorship: Working under Prof. Nallathamby or graduate students or senior udnergraudates in a collaborative setting allows for high-level technical training in a cutting-edge field of precision medicine.
- Co-authorships or Lead authorships on peer reviewed publications