Using Raman Spectroscopy to Decode Low-Frequency Molecular Vibrations
Existing vibrational spectroscopy databases do not report ultra-low-frequency Raman signals. This is because, until recently, such measurements were only possible using complex far-infrared or terahertz spectroscopy techniques. However, this spectral region provides unique insights into molecules, polymers, crystal lattices and other solid-state structures by probing intermolecular interactions and phonon vibrations within these systems. Recent innovation in filter optics, lasers, and detectors now enable Raman measurements very close to the excitation laser line (<10 cm-1), meaning we now have the capabilities to expand the study of Raman spectra to cover this low-frequency region and identify hidden spectral features of fundamental significance.
Students will acquire Raman spectra of multiple analytes and compile them into a reference database that spans a broader spectral range than previously reported. In parallel with database creation, the student will explore tools to extract information from the database and extend predictions to unknown samples using machine learning or artificial intelligence.
Our lab currently hosts five graduate students, two undergraduate students, and two high school students. Our highly collaborative research environment enables students to build diverse networks and gain exposure to a broad scientific community both within and outside Notre Dame. To date, we have mentored >40 undergraduates, many of whom have co-authored peer-reviewed publications and continued into graduate, medical, and professional schools. In our lab, students get a comprehensive, holistic view of the scientific process, allowing them to not only gain essential research skills, but also the ability to explore potential career paths in science.